First-half strikes from Spinazzola and Amir Rrahmani earned a win for Napoli at the Stadio Olimpico in a fixture marred by multiple sendings-off.
This result pushes Conte's side to within a single point of Italian league pace-setters Milan, who prevailed on Friday. Inter hold third place but can return to the top with a victory in their evening match.
Control Despite Absences
Hampered by the absence of several key players, Napoli controlled the proceedings with patient build-up play. The first goal came when Politano's cross was volleyed home by the wing-back at the far post.
The lead was doubled in the first half as the defender powered a glancing header from a Politano set-piece into the net. They went close to a third shortly after when Elmas watched his header crash against the woodwork.
Tempers Flare and Red Cards
After the break saw more injury concern for the visitors when a player was forced off. The stoppage sparked a brief altercation, leading to yellow cards for Rrahmani and Lazio's Noslin—who then received a second yellow for a challenge.
"I must congratulate the lads, playing with this level of quality and physical strength while preventing Lazio play is difficult," remarked the winning manager. "Our performance was at a exceptional level of play."
Tempers boiled over again late on as two opponents became involved in a fierce exchange, prompting the manager to step in. The two players were sent off for their part in the clash.
Elsewhere European Action
Over in La Liga, the Andalusian side suffered a 3-0 defeat at home to lowly Levante. The visitors established a lead with a fine move before adding two further strikes in the second period to complete a convincing win.
Meanwhile, Real Madrid host significant must-win when they play Betis, after their rivals extended their lead at the top. In the day's late match, Atlético Madrid travel to face La Real.
Turning to Ligue 1, a historic capital derby is scheduled as Paris FC visit powerhouses PSG. The fixture represents the first top-flight encounter between the neighbors in over 36 years, adding extra spice to the weekend's action.